Developing new and better ways to manage adverse symptoms is vital to improving quality of life for those living with acute and chronic illness. The Symptom Management Branch is dedicated to improving the understanding of the underlying biological mechanisms of a range of symptoms, their effect on patients, and the biological and behavioral bases for how patients respond to interventions. The research focuses on the following areas:

Genomic and Clinical Biomarkers Unit (Principal Investigator: Dr. Ann Cashion)

The Clinical Biomarker Unit conducts research to discover biomarkers, within an environmental and clinical context, to predict patient outcomes and guide therapies specifically in solid organ transplant recipients, but also expanding to other diseases/disorders and patient populations.  For solid organ transplant recipients, the goal is to discover biomarkers that will identify those patients most at risk for weight gain, and, that can be used to provide personalized strategies to prevent weight gain and resulting co-morbidities (e.g., diabetes and cardiovascular disease).

Symptom Biology Unit (Principal Investigator: Dr. Leorey Saligan)

Research in this area examines the nature and causes of fatigue, in relation to conditions such as sarcoidosis and in association with cancer treatments. In addition, research focuses on pain associated with fibromyalgia.

Cardiovascular Symptoms Unit (Principal Investigator: Dr. Marguerite Engler)

Research in this area focuses on vasculoprotective nutritional interventions that may improve the lipid profile in hyperlipidemia and decrease high blood pressure in hypertension.

For more about Symptom Management, visit Symptom Management Research at NINR. 

For more information: 

DIR Home Page: More information about NINR's intramural research
DIR Staff Directory: Staff listings, principal investigator profiles, and contact information