Karen Daley, PhD, MPH, RN, FAAN
Dr. Karen Daley was elected in 2010 as the president of the American Nurses Association, the nation’s largest nursing organization representing the interests of the nation’s 3.1 million registered nurses. President Daley spent more than 26 years as a staff nurse at Brigham and Women’s Hospital in Boston. She is a past president of the Massachusetts Association of Registered Nurses and the Massachusetts Center for Nursing. In addition, she has served on the boards of ANA, the American Nurses Credentialing Center, and the ANA-PAC. As a vocal, nationally recognized advocate for legislation mandating the use of safer needle devices in health care practice settings, President Daley has traveled throughout the world raising awareness among nurses, legislators, and health care administrators on the importance of needlestick prevention. She was among those invited to the Oval Office to witness President Clinton sign the “Needlestick Safety Prevention Act” into law on November 6, 2000. President Daley has also been recognized for her outstanding leadership and excellence in practice, including being recognized as a living nursing legend by the Massachusetts Association of Registered Nurses. In 2006, she was inducted as a fellow into the American Academy of Nursing in recognition of her advocacy work in needlestick prevention.In addition to her work as a practicing nurse and nurse advocate, President Daley is an experienced nurse researcher and writer.
She has authored numerous articles on nursing and health care, and served as a staff writer for the Bay State Nurse News. Currently, she is a reviewer for the Journal of Emergency Nursing, the American Journal of Nursing and the American Journal of Infection Control. In addition, President Daley served as a project principal for the Nurses Education Hepatitis C Project funded by the Massachusetts Department of Public Health as well as a project coordinator for a trauma research study conducted by the Harvard Injury Control Center at the Harvard School of Public Health. A resident of Boston, Massachusetts, President Daley holds a diploma in nursing from Catherine Laboure School of Nursing, a bachelor’s of science in nursing from Curry College, a master’s in public health from Boston University School of Public Health, a master’s in science and PhD in nursing from Boston College.
Michael M. Gottesman, MD
Michael Marc Gottesman is Deputy Director for Intramural Research at NIH, and Chief of the Laboratory of Cell Biology, National Cancer Institute (NCI), National Institutes of Health (NIH). He was born on October 7, 1946 in Jersey City, New Jersey and attended Harvard College where he graduated summa cum laude in biochemical sciences in 1966. He was married the same year to Susan Kemelhor. He graduated from Harvard Medical School with an M.D. magna cum laude in 1970 and completed a medical internship and residency at the Peter Bent Brigham Hospital in Boston. His research training began at Harvard in the laboratories of William Beck and Bert Vallee, and continued in the laboratory of Martin Gellert at the National Institutes of Health as a Research Associate from 1971 to 1974. Dr. Gottesman spent a year as an Assistant Professor at Harvard Medical School and then, together with his wife who is a bacterial geneticist, joined the permanent staff of the National Cancer Institute in 1976. He became Chief of the Molecular Cell Genetics Section of the Laboratory of Molecular Biology in 1980, Chief of the Laboratory of Cell Biology in 1990, Acting Director of the National Center for Human Genome Research (NCHGR) from 1992 to 1993, and also Acting Scientific Director of the NCHGR (April 1993 to October 1993). He has been Deputy Director for Intramural Research, NIH, since November 1993, and was Assistant Surgeon General (Rear Admiral), Public Health Service from 1997 to 2000.
At the NIH his research interests have ranged from how DNA is replicated in bacteria to how cancer cells elude chemotherapy. He has published over 400 peer-reviewed papers. Using chloramphenicol resistance as a model, he was one of the first to show that drug resistance genes could move from one replicon to another in bacteria. Applying the tools of molecular and somatic cell genetics to the study of cAMP-resistance and anti-microtubule drug resistance in mammalian cells, he isolated and characterized cAMP-dependent protein kinase mutants and conditional alpha- and beta-tubulin mutants. He was among the first to exploit novel techniques of DNA transfer in somatic cells, while using them as tools to demonstrate the role of cAMP-dependent kinase in growth regulation and to study the effect of microtubule defects on mitosis. The work on anti-microtubule drug resistance led to studies on multidrug resistance in human cancer cells. During the past 25 years he has identified and characterized the human MDR1 gene, the first of the mammalian ABC transporter genes to be described as that responsible for resistance of cancer cells to many of the most common anticancer drugs. This research has shown that this gene encodes a protein that acts to pump anticancer drugs out of drug-resistant human cancers. In addition to the development of strategies to circumvent multidrug resistance in cancer, these studies have led to a new generation of selectable vectors for gene therapy, and the discovery of other members of the ABC transporter family as drug-resistance genes. At least 20 human ABC transporters contribute to anticancer drug resistance, and identification of their substrates has enabled the development of new lead compounds that specifically kill MDR cells. Most recently, his laboratory has used gene expression analysis to correlate patient response to chemotherapy with expression of MDR genes.
Dr. Gottesman's professional activities include many active memberships in professional societies and editorial boards. He was elected a Fellow of the American Association for the Advancement of Science (AAAS), 1988; the Institute of Medicine of the National Academies, 2003; the Association of American Physicians (AAP), 2007, and the American Association of Arts and Sciences, 2010. His awards and honors are numerous and, to name a few, include the Milken Family Foundation Cancer Research Award, 1988; Rosenthal Foundation Award, 1992; American Society of Pharmacology and Experimental Therapeutics (ASPET) Award, 1997; Public Health Service Commissioned Corps Meritorious Service Medal, 1999; NIH Director’s Award, 2002; Department of Health and Human Services (DHHS) Secretary’s Award for Distinguished Service, May 2005; and the 6th Alan S. Rabson, M.D. Award for NCI Intramural Cancer Research, January 2010.
Dr. Gottesman has been actively involved in initiating several training and mentoring programs for high school students and teachers, college students, graduate students, and post-doctoral students. As Deputy Director for Intramural Research at the NIH, he has initiated an NIH-wide lecture series, reformulated tenure and review processes in the intramural program, initiated multiple trans-NIH research initiatives, and has instituted training programs for disadvantaged students. He has also overseen the creation of loan repayment programs for laboratory and clinical researchers, a clinical research training program for medical students, and formalized institutional training and mentoring for postdoctoral fellows at the NIH.
The Honorable Daniel K. Inouye
United States Senator, Hawaii
Daniel K. Inouye, the most senior member of the U.S. Senate and the President Pro-Tempore, is known for his distinguished record as a legislative leader, and as a World War II combat veteran with the 442nd Regimental Combat Team, who earned the nation’s highest award for military valor, the Medal of Honor.
Although he was thrust into the limelight in the 1970s as a member of the Watergate Committee and in 1987 as Chairman of the Iran-Contra Committee, he has also made his mark as a respected legislator able to work in a bipartisan fashion to enact meaningful legislation.
As Chairman of the Senate Appropriations Committee and of the Senate Defense Appropriations Subcommittee, Senator Inouye has been able to focus on defense matters that strengthen national security, and enhance the quality of life for military personnel and their families. This reflects his hope for a more secure world, and his desire to provide the best possible assistance to the men and women who put their lives at risk to protect the United States.
In addition, he is the Ranking Democrat on the Commerce, Science & Transportation Committee and the Indian Affairs Committee and sits on the Rules Committee. He helped establish the Inter-parliamentary Exchange Program between the U.S. Senate and Japan’s legislature, and in 2000 the Government of Japan presented him with the Grand Cordon of the Order of the Rising Sun.
Early in his tenure in the Senate, Senator Inouye delivered the keynote address at the 1968 Democratic National Convention, and was under consideration to become Hubert Humphrey’s vice-presidential running mate that same year. He became the first Chairman of the Senate Select Committee on Intelligence in 1976, served as the third-ranking leader among Senate Democrats as Secretary of the Democratic Conference from January 1979 through 1988. He chaired the Senate Democratic Central America Study Group to assess U.S. policy and served as Senior Counselor to the National Bipartisan Commission on Central America (also known as the Kissinger Commission).
Senator Inouye has championed the interest of Hawaii’s people throughout his career. With his support, Hawaii’s infrastructure has been strengthened, its economy diversified, and its natural resources protected and restored. For local residents, particularly Native Hawaiians, whose history and welcoming culture give the state its defining characteristics, Senator Inouye has increased job training and employment opportunities, provided more community healthcare, and provided support services and research to help small businesses and diverse sectors, from agriculture to high technology.
His imprint is seen on all of the state’s islands through initiatives such as Honolulu and Neighbor Island bus service, steady construction jobs in support of military infrastructure, the diversification of agriculture, the birth of the Kauai High Technology Center and the rise of the Pacific Missile Range Facility, the launch of the Maui supercomputer, the expansion of national parks and wildlife refuges in Hawaii, and the protection of Hawaiian monk seals, sea turtles, the alala (Hawaiian crow), the nene goose and coral reefs.
Senator Inouye got his start in politics in 1954 when he was elected to the Territorial House of Representatives; soon after his election, his Democratic colleagues, well aware of Inouye’s leadership abilities, selected him as their Majority Leader. In 1958 he was elected to the Territorial Senate. When Hawaii became a state in 1959, he was elected the first Congressman from the new state, and was re-elected to a full term in 1960. He was first elected to the U.S. Senate in 1962 and is now serving his eighth consecutive term.
On May 24, 2008, Senator Inouye married Irene Hirano, who is President of the U.S.-Japan Council. He was married for nearly 57 years to Margaret Awamura Inouye, a former instructor at the University of Hawaii, who passed away on March 13, 2006. He has a son, Ken, who is married to Jessica Carroll from Rochester, New York, and a granddaughter Mary Margaret “Maggie” Inouye.
Howard K. Koh, MD, MPH
Assistant Secretary for Health
U.S. Department of Health and Human Services
Dr. Howard K. Koh serves as the 14th Assistant Secretary for Health for the U.S. Department of Health and Human Services (HHS), after being nominated by President Barack Obama and confirmed by the U.S. Senate in 2009. Dr. Koh oversees 14 core public health offices, including the Office of the Surgeon General and the U.S. Public Health Service Commissioned Corps, 10 Regional Health Offices across the nation, and 10 Presidential and Secretarial advisory committees. He also serves as senior public health advisor to the Secretary. The Office of Assistant Secretary for Health implements an array of interdisciplinary programs relating to disease prevention, health promotion, the reduction of health disparities, women’s and minority health, adolescent health, HIV/AIDS and chronic infectious diseases, vaccine programs, fitness, sports and nutrition, bioethics, population affairs, blood supply, research integrity and human research protections. As the Assistant Secretary for Health, Dr. Koh is dedicated to the mission of creating better public health systems for prevention and care so that all people can reach their highest attainable standard of health.
Dr. Koh previously served as the Harvey V. Fineberg Professor of the Practice of Public Health and Associate Dean for Public Health Practice at the Harvard School of Public Health. He was also Director of the Harvard School of Public Health Center for Public Health Preparedness. As Commissioner of Public Health for the Commonwealth of Massachusetts, Dr. Koh led the Massachusetts Department of Public Health, where he emphasized the power of prevention and strengthened the state’s commitment to eliminating health disparities. During his service, the state saw advances in tobacco control, cancer screening, newborn screening, organ donation, suicide prevention, health issues of the homeless, and international public health partnerships.
Dr. Koh graduated from Yale College, where he was President of the Yale Glee Club, and the Yale University School of Medicine. He completed postgraduate training at Boston City Hospital and Massachusetts General Hospital, serving as chief resident in both hospitals. He has earned board certification in four medical fields: internal medicine, hematology, oncology, and dermatology, as well as a Master of Public Health degree from Boston University. At Boston University Schools of Medicine and Public Health, he was Professor of Dermatology, Medicine and Public Health, as well as Director of Cancer Prevention and Control.
He has earned numerous awards and honors for interdisciplinary accomplishments in medicine and public health, including the Distinguished Service Award from the American Cancer Society and the Drs. Jack E. White/LaSalle D. Leffall Cancer Prevention Award from the American Association for Cancer Research and the Intercultural Cancer Council.
He is an elected member of the Institute of Medicine and was appointed by President Bill Clinton to the National Cancer Advisory Board (2000-2002). Dr. Koh was named by the New England Division of the American Cancer Society as “one of the most influential persons in the fight against tobacco during the last 25 years” and is one of the K100 (the 100 leading Korean Americans in the first century of Korean immigration to the United States).