Paule V. Joseph, PhD, MS, FNP-BC, RN, CTN-B

Dr. Paule V. JosephSensory Biology and Metabolism Unit
Biobehavioral Branch
Division of Intramural Research

Research Topics

Each year, over 200,000 people visit a medical provider for chemosensory problems such as taste and smell disorders. Lifestyle modifications, including diet changes, are a primary treatment. However, when smell-taste perception is distorted and poorly treated, altered eating may still occur thus worsening the condition. As a gastrointestinal nurse and family nurse practitioner, Dr. Paule Joseph has extensively worked with individuals with diabetes and obesity, and with individuals undergoing bariatric surgery. Together, her research and clinical experiences led her to appreciate the complexity of the interplay of biological and behavioral components in addressing symptoms and managing obesity and eating disorders. Dr. Joseph brings a unique and necessary perspective to the study of chemosensory symptoms (taste and smell alterations) by incorporating both clinical and bench science approaches to unite three fields of science: nursing, sensory biology, and omics.

Dr. Joseph is an Assistant Clinical Investigator and Chief of the Sensory Science and Metabolism Unit (SenSMet) in the NINR Division of Intramural Research. The SenSMet supports research into the fundamental mechanisms associated with chemosensory symptoms and metabolic conditions such as Type 2 diabetes, obesity, and related comorbidities. Dr. Joseph’s clinical chemosensory research aims to improve the diagnosis, prevention, and management of chemosensory disorders and symptoms. This research will enhance the understanding of molecular, cellular, neural, and behavioral mechanisms underlying symptoms to identify new targets for treatment and improve symptom management strategies.

Current research supported in the SenSMet includes studies to:

  • Characterize the function of obesity susceptibility gene variants that were previously identified in adipose (fat storage) tissue via expression studies.
  • Examine the Oral-Brain-Gut Axis and its role in metabolism by analyzing "omic" and clinical data to predict diabetes and obesity risk and chemosensory and metabolic drivers of eating behavior and associated outcomes.
  • Describe the interaction of diet and the microbiome (i.e., the micro-organisms that inhabit the gastrointestinal tract) in influencing oral, nasal, and gut physiology.


After earning her PhD in Nursing with a focus in Genomics from the University of Pennsylvania and The Monell Chemical Senses Center, Dr. Paule Joseph completed a Workforce Diversity Postdoctoral Fellowship at the NINR, in the laboratory of Dr. Wendy Henderson. Her postdoctoral research focused on combining clinical and basic research in a single research program through examining the brain-gut interactions related to gastrointestinal disorders (i.e., obesity and diabetes). In 2017, she was appointed as Assistant Clinical Investigator and Chief of the Sensory Science and Metabolism Unit (SenSMet) in the NINR Division of Intramural Research. Dr. Joseph has a Master's of Science as Family Nurse Practitioner from Pace University, an AAS in Nursing at Hostos Community College, and a BSN from the College of New Rochelle. She is also a certified nurse practitioner. She has worked as a clinical nurse at The Mount Sinai Hospital and at Columbia Presbyterian-Weill Cornell Hospital. Dr. Joseph has practiced nursing in the areas of rehabilitation medicine and gastrointestinal medicine and surgery. She has served as co-chair for the metabolic special interest group of the International Society of Nurses in Genetics and as a board member of the National Hispanic Nurses Association. Dr. Joseph is also co-founder of the Latino Nurses Network. She is the recipient of several awards including the Johnson & Johnson-American Association of Colleges of Nursing's Minority Nurse Faculty Scholarship and the Rockefeller University Heilbrunn Nurse Scholar Award. She is a fellow of the New York Academy of Medicine and an international Transcultural Nurse Fellow. Her career goal is to lead, represent, and mentor future research leaders from diverse and disadvantaged backgrounds.

Selected Publications

Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome.
Sherwin LB, Ozoji OM, Boulineaux CM, Joseph PV, Fourie NH, Abey SK, Zhang X, Henderson WA. J Clin Med. 2017 Nov 1;6(11). pii: E103. doi: 10.3390/jcm6110103. PMID: 29104254

Data supporting the effects of lysozyme on mRNA and protein expression in a colonic epithelial scratch wound model.
Abey SK, Yuana Y, Joseph PV, Kenea ND, Fourie NH, Sherwin LB, Gonye GE, Smyser PA, Stempinski ES, Boulineaux CM, Weaver KR, Bleck CK, Henderson WA.
Data Brief. 2016 Dec 29; 11:15-18. doi: 10.1016/j.dib.2016.12.043. eCollection 2017 Apr. PMID: 28119952

Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress.
Abey SK, Yuana Y, Joseph PV, Kenea ND, Fourie NH, Sherwin LB, Gonye GE, Smyser PA, Stempinski ES, Boulineaux CM, Weaver KR, Bleck CK, Henderson WA.
BBA Clin. 2016 Dec 20; 7:23-35. doi: 10.1016/j.bbacli.2016.12.003. eCollection 2017 Jun. PMID: 28053879

Emerging Role of Nutri-Epigenetics in Inflammation and Cancer.
Joseph PV, Abey SK, Henderson WA.
Oncol Nurs Forum. 2016 Nov 1;43(6):784-788.
PMID: 27768134

The microbiome of the oral mucosa in irritable bowel syndrome.Fourie NH, Wang D, Abey SK, Sherwin LB, Joseph PV, Rahim-Williams B, Ferguson EG, Henderson WA.Gut Microbes. 2016 Jul 3;7(4):286-301. Epub 2016 Mar 10. PMID: 26963804

Individual Differences Among Children in Sucrose Detection Thresholds: Relationship With Age, Gender, and Bitter Taste Genotype.
Joseph PV, Reed DR, Mennella JA. Nurs Res. 2016 Jan-Feb;65(1):3-12. doi: 10.1097/NNR.0000000000000138. PMID: 26633761

MYTHS & FACTS: ... About neuromyelitis optica.
Joseph PV. Nursing. 2009 Sep;39(9):16. doi: 10.1097/01.NURSE.0000360239.28748.52. No abstract available. PMID: 19701008