NINR Director Dr. Shannon Zenk and fellow Executive Committee Co-Chairs of the NIH-wide Social Determinants of Health Research Coordinating Committee authored an editorial published in JAMA Internal Medicine on prioritizing research on social determinants of health (SDOH). A key research lens in NINR’s Strategic Plan, SDOH refers to the conditions in which people are born, grow, learn, play, live, and age, as well as the structural factors that shape them. The authors encourage embracing a transdisciplinary approach guided by the NIH conceptualization of SDOH and actionable research targeting upstream factors to propel this area forward. They emphasize the importance of investing resources into SDOH research to maximize our understanding of health and the impact of innovative solutions to address health disparities and advance health for all people.